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Disclosures: Grace Lai-Hung Wong: AstraZeneca, Gilead Sciences, GlaxoSmithKline and Janssen,: Advisor, Abbott, AbbVie, Ascletis, Bristol-Myers Squibb, Echosens, Gi: Speaking and Teaching, Gilead Sciences: Grant/Research Support, Mario Alvares-da-Silva: Nothing to Disclose, Fatima Higuera-de-la-Tijera: Nothing to Disclose, Ming-Lung Yu: Abbvie, Gilead and Roche diagnostics.: Grant/Research Support, Abbott, Abbvie, Gilead, Roche and Roche diagnostics: Consultant, Abbvie, BMS, Gilead, Roche and Roche diagnostics: Speaking and Teaching, Soo Aleman: Gilead: Speaking and Teaching, Francisco Javier García-Samaniego Rey: Gilead

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This triggers the activation of AMP-activated protein kinase (AMPK), a key energy sensor that phosphorylates and stimulates the TSC complex, leading to the inhibition of RHEB and subsequent mTORC1 suppression (Fig